Tsis ntev los no, qhov hnyav thoob ntiaj teb nyiam - poob "miracle tshuaj" - Semaglutide - yog ib qho tshiab ntev - ua glucagon- zoo li peptide-1 (GLP-1) receptor agonist. Hauv cov tshuaj, peb feem ntau ntsib cov ntsiab lus zoo sib xws, yog li cia peb rhuav tshem nws ib kauj ruam.
Ua ntej, peb pib nrog lub hauv paus ntawm yuav ua li cas cov tshuaj no ua haujlwm: glucagon-zoo li peptide-1 (GLP-1).
GLP-1 yog cov tshuaj hormones zais los ntawm txoj hnyuv. Nws txhim kho insulin secretion hauv qabzib-raws li txoj hauv kev, inhibits glucagon secretion, qeeb plab hnyuv, thiab txo cov khoom noj los ntawm kev noj qab haus huv hauv nruab nrab, yog li ua tiav ob qho qabzib- txo qis thiab txo qhov hnyav.
Mechanisms ntawm GLP-1 (Glucagon-zoo li Peptide-1)
Txhawb nqa insulin synthesis thiab secretion
GLP-1 khi rau receptors ntawm pancreatic -cells thiab ua kom muaj kev taw qhia xws li cAMP/PKA thiab IP3/Ca²⁺, nce insulin ntau lawm thiab tso tawm.
Inhibits glucagon secretion
Nws inhibits glucagon tso tawm ntawm pancreatic -cells, ntxiv txo cov ntshav qabzib.
Delays plab hnyuv
GLP-1 inhibits gastrointestinal motility thiab gastric secretion, slowing gastric emptying thiab txo postprandial ntshav qabzib spikes.
Suppresses qab los noj mov
Nws ua rau lub chaw hypothalamic satiety, txo cov khoom noj kom tsawg thiab lub cev hnyav nce.
Tiv thaiv pancreatic -cells
GLP-1 txhawb nqa -cell proliferation thiab sib txawv thaum inhibiting apoptosis, yog li khaws cia ua haujlwm pancreatic.
Hauv cov ntsiab lus, GLP-1 yog ib qho tshwm sim ntau yam tshuaj hormones uas txo cov ntshav qabzib thiab tseem ua rau poob phaus thiab tiv thaiv pancreatic.
Dab tsi yog receptor agonist?
Lub receptor agonist yog ib yam khoom uas khi rau cov receptors tshwj xeeb ntawm cov cell membrane zoo li cov tshuaj hormones thiab ua rau lawv ua haujlwm, ua rau muaj cov tshuaj lom neeg biochemical uas tsim cov tshuaj hormones -zoo li cov teebmeem physiological.
Cov txheej txheem no feem ntau suav nrog G protein-coupled receptor (GPCR) signaling. Tom qab khi, tus receptor hloov nws cov qauv thiab ua kom cov G proteins, uas tom qab ntawd txhawb cov nyhuv downstream xws li adenylyl cyclase (AC) thiab phospholipase C (PLC). Qhov no ua rau kev tsim cov tub txib thib ob xws li cAMP, DAG, thiab IP3, uas txuas ntxiv ua kom cov protein kinases thiab ion channels, thaum kawg tsim cov lus teb tshwj xeeb.
Hauv cov ntsiab lus yooj yim, receptor agonist yog cov khoom siv hluavtaws uas ua rau cov tshuaj hormones ntuj tsim thiab nkag mus rau hauv lub cev kom ua rau muaj kev cuam tshuam zoo sib xws.
GLP-1 vs GLP-1 receptor agonists
Ib txwm tshwm sim GLP-1 yog cov tshuaj hauv plab hnyuv uas khi rau GLP-1 receptors ntawm pancreatic -cells, txhawb cov tshuaj insulin gene transcription, nce insulin synthesis thiab secretion, inhibiting glucagon secretion, thiab txo cov ntshav qabzib.
GLP-1 receptor agonists yog cov tshuaj hluavtaws nrog cov qauv zoo ib yam li ntuj GLP-1. Lawv khi rau tib lub receptors thiab tsim cov tshuaj lom neeg zoo sib xws, suav nrog kev txhawb nqa cov tshuaj insulin secretion, inhibiting glucagon tso tawm, thiab ncua lub plab zom mov, yog li txo cov ntshav qab zib.
Txawm li cas los xij, GLP-1 receptor agonists tsis tsim cov tshuaj hormones, yog li lawv cov kev mob tshwm sim thiab kev pheej hmoo yuav tsum tau ua tib zoo xav thaum siv.
Qhov zoo ntawm ntev - ua haujlwm GLP-1 receptor agonists
Muab piv rau endogenous GLP-1, ntev- ua haujlwm GLP-1 receptor agonists muaj lub neej ntev dua thiab ruaj khov dua, tso cai rau lawv ua haujlwm ntev dua thiab muab cov glycemic zoo dua thiab tswj qhov hnyav. Lawv muab cov kev kho mob tshiab rau cov neeg mob ntshav qab zib hom 2, tshwj xeeb tshaj yog cov uas tsis ua tiav kev tswj hwm zoo nrog cov tshuaj ib txwm muaj.
Kev loj hlob ntawm Semaglutide
Thaum lub sij hawm txoj kev loj hlob, Novo Nordisk pab neeg tshawb fawb optimized cov qauv molecular ntawm Semaglutide:
Ntawm txoj hauj lwm 8, alanine tau hloov nrog -aminoisobutyric acid (Aib) los tiv thaiv kev degradation los ntawm DPP-4 thiab txhim kho receptor affinity.
Ntawm txoj hauj lwm 26, C18 fatty acid saw txuas los ntawm glutamic acid linker kom nce albumin binding, txo lub raum clearance, thiab ntev ib nrab -lub neej.
Txhawm rau ua kom muaj kev tswj hwm qhov ncauj, SNAC (sodium N-(8-[2-hydroxybenzoyl] amino) octanoate) tau siv los ua kev nqus dej txhawm rau txhim kho plab zom mov thiab kev nqus.
Kev sim tshuaj thiab kev pom zoo
Tom qab kev sim tshuaj, kev txhaj tshuaj Semaglutide tau pom zoo los ntawm US FDA thaum Lub Kaum Ob Hlis 2017 rau kev tswj glycemic rau cov neeg laus uas muaj ntshav qab zib hom 2.
Tom qab ntawd, lub ntiaj teb STEP qhov kev sim tshuaj ntsuam xyuas (kwv yees li 4,500 tus neeg koom) tau ntsuas nws qhov hnyav - cov teebmeem poob:
Tom qab 12 lub lis piam: qhov hnyav poob qis ~ 6%
Tom qab 68 lub lis piam: poob phaus ~ 17-18%
Cov kev mob tshwm sim feem ntau suav nrog kev mob plab hnyuv xws li xeev siab, ntuav, thiab raws plab.
Raws li cov txiaj ntsig no, FDA pom zoo Semaglutide rau kev tswj qhov hnyav thaum Lub Rau Hli 2021.
Hauv Suav teb, nws tau pom zoo rau lub Plaub Hlis 2021 rau kev kho mob ntshav qab zib hom 2 tab sis tseem tsis tau pom zoo rau kev poob phaus.
Kev ua lag luam
Los ntawm 2022, Semaglutide kev muag khoom thoob ntiaj teb tau txog $ 5.93 nphom, nce 77%, dhau los ua Novo Nordisk thib ob - cov khoom loj tshaj plaws.
Hauv Suav teb, lub khw muag tshuaj GLP-1 tau txog li 5.7 billion RMB hauv xyoo 2022, nrog Semaglutide suav txog kwv yees li 2.2 billion RMB.
Nrog nce ntshav qab zib thiab rog rog, GLP-1 kev lag luam txuas ntxiv nthuav dav.
Hauv Tebchaws Meskas, ntau tus GLP-1 agonists tau pom zoo rau kev poob phaus. Hauv Suav teb, txawm tias tseem tsis tau pom zoo rau qhov kev qhia no, yav tom ntej muaj peev xwm tseem ceeb.
Kev kwv yees hais tias Tuam Tshoj tus GLP-1 kev kho mob rog rog kev lag luam tuaj yeem tshaj 20-40 billion RMB.
Vim li cas Semaglutide txhawb kev poob phaus
Semaglutide yog qhov tseem ceeb ntawm peptide hormone. Cov tshuaj hormones ua haujlwm zoo li cov teeb liab sib txuas lus: thaum lub teeb liab tau txais los ntawm receptors, cov teebmeem lom neeg tshwj xeeb tau tshwm sim.
GLP-1 tsis tsuas yog txhawb kev tso tawm cov tshuaj insulin xwb tab sis kuj sib txuas lus nrog lub hlwb, qhia tias satiety ("koj puv, tsis noj").
Qhov kev ua haujlwm dual no piav qhia nws qhov hnyav - poob.
Kev tshawb fawb qhia tias Semaglutide ua feem ntau los ntawm lub hlwb:
Activates GLP-1 receptors hauv lub hlwb
Stimulates POMC/CART neurons ntawm GABA- nyob ntawm txoj kev
Inhibits NPY/AgRP neurons
Txo tag nrho lub zog kom tsawg li ~ 20%
Nws kuj txo cov kev nyiam rau cov khoom noj qab zib siab - rog thiab siab -.
Hauv cov ntsiab lus yooj yim: tom qab txhaj tshuaj, cov zaub mov tsis txaus nyiam, kev xav tau qis dua, thiab cov neeg mob txo cov zaub mov noj.
Kev xav txog kev nyab xeeb
Piv nrog rau qhov hnyav dhau los-cov tshuaj poob (xws li amphetamines lossis sibutramine), uas ua rau lub hauv nruab nrab lub paj hlwb thiab muaj kev pheej hmoo xws li kev quav yeeb quav tshuaj, kev nyuaj siab, thiab mob plawv, Semaglutide feem ntau suav tias muaj kev nyab xeeb dua.
Nws cov kev mob tshwm sim feem ntau yog plab hnyuv (xws li xeev siab, ntuav), uas feem ntau zam tau ntau dua.
Txawm li cas los xij, qhov ntev - tseem tab tom kawm txog kev pheej hmoo, thiab nws tsuas yog yuav tsum tau siv nyob rau hauv kev saib xyuas kho mob.
Kev txhim kho yav tom ntej
Txij li thaum qhov kev tshawb pom ntawm natural GLP-1, GLP-1 receptor agonists tau hloov zuj zus los ntawm kev ua haujlwm luv luv mus rau cov neeg ua haujlwm ntev, nthuav dav los ntawm kev kho mob ntshav qab zib kom poob phaus, thiab muaj feem cuam tshuam rau cov kab mob plawv, kab mob raum, kab mob siab rog, thiab txawm tias Alzheimer's disease.
Thaum Lub Peb Hlis, FDA tau pom zoo Wegovy rau txo qis kev pheej hmoo ntawm cov hlab plawv hauv cov neeg laus rog lossis rog rog nrog cov kab mob plawv.
GLP-1 tshuaj tab tom tsom rau ntau yam kabmob - daim siab, hlwb, plab, txiav, thiab raum - thiab lawv cov peev xwm kho tau txuas ntxiv.
Yog xav yuavSemaglutide Peptide 10 mg thiab xav kawm ntxiv lwm yam khoom, thov hu rau Xi'an Ruichi. Peb tos ntsoov yuav hnov los ntawm koj.
Email:Jenny@ruichibio.com
Siv:https://www.ruichibio.com/lyophilized-peptide/semaglutide-peptide-10mg.html